- RNA pieces in the spliceosome, has a domain
V counterpart, containing a 2-nucleotide
bulge located 5 base pairs away from an AGC
triad (10).
- Formation of an analogous metalbinding
platform in this region of U6 (11) may
explain the apparent ability of spliceosomal
RNAs to retain catalytic activity in the complete
absence of the many protein components
that usually accompany splicing (12).
- A
domain V-like element could have played a
major role during the RNA world era of evolution,
serving as the catalytic center for RNA
cleavage, transesterifiation, and polymerization
reactions.
- Natl.
- Acad.
- Sci. U.S.A. 90, 6498
(1993).
6. L. Zhang, J. A. Doudna, Science 295, 2084 (2002).
...
R08-009(D),051414 PC# 1412 - EnvGrps Att 1-6 
