V counterpart, containing a 2-nucleotidebulge located 5 base pairs away from an AGCtriad (10).
Formation of an analogous metalbinding
platform in this region of U6 (11) mayexplain the apparent ability of spliceosomalRNAs to retain catalytic activity in the complete absence of the many protein componentsthat usually accompany splicing (12).
A
domain V-like element could have played amajor role during the RNA world era of evolution, serving as the catalytic center for RNAcleavage, transesterifiation, and polymerization reactions.
Natl.
Acad.
Sci. U.S.A. 90, 6498
(1993).6. L. Zhang, J. A. Doudna, Science 295, 2084 (2002)....
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